This LIF network with Ca plasticity is based on: David Higgins, Michael Graupner, Nicolas Brunel Memory Maintenance in Synapses with Calcium-Based Plasticity in the Presence of Background Activity PLOS Computational Biology, 2014
This tutorial shows how one can assemble a complex multiscale neuronal model by combining morphology definitions with spine distributions, channel definitions and distribution, and model files for chemical signaling and how they are distributed over the cell.
The MOOSE has been evolving rapidly in the direction of rapidly compising multiscale (chemical + electrical) models and displaying them. The image shows a model with 50 compartments and 50 spines. The dendrite is divided into 100 chemical voxels, and each spine and PSD also contain separate but coupled chemical reaction systems.
3-D display with the oscillating reaction-diffusion system with electrical model having 1 compartments and 0 spines where chemical part of model has 250 dendrite voxels X 3 pools.
PSD MultiCompartment Model
Three-compartment reaction scheme for CaMKII activation, translocation and receptor trafficking